What is electrostatic spraying?

Electrostatic spraying involves applying a charge to a sprayed fluid that utilizes the simple rules of attraction (opposite forces) and repulsion (like forces) forming a mist that will wrap around objects and disperse in a thin uniform coating across the surface.

Improved Adhesion and Infiltration

Electrostatically charged therapeutics facilitate instant adhesion to the target tissue.

 

As a result of the charge, the droplets migrate deeper into complex wound topographies.

Advantages of electrostatic spraying

Comprehensive Wound Coverage

Electrostatically charged particles allow for a uniform dispersion of the therapeutic.

The electrostatically charged particles will inherently ‘wrap’ the target tissue ensuring complete coverage - even in and on nonuniform surface target tissue.

Published data supports the advantages of using electrostatics to enhance the objective of achieving optimal coverage. (1,2)

Clinical Implications

Enhances the potential for maximizing the desired outcome of applying a specific therapeutic to a targeted tissue.

Electrostatically applied therapeutics can cover a larger area using less volume compared to traditional application methods.

What is electrospinning?

Electrospinning is a fiber production method that uses electrical force to draw charged fibers out of polymer solutions.  In our application, we will be spinning a wide range of polymers to produce a nanofiber wound dressing.(2)

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Compositional Mimicry

Electrospinning can produce a 3D ‘basket-weave’ structure that can mimic the extracellular matrix of the dermis. Unlike traditional dressings, the electrospun fibers can conform to the various wound dimensions and contours.

Advantages of electrospun wound dressings

Structural Mimicry

Electrospun fibers conform to the wound bed topography while the semi-permeability of the fibrous matrix facilitates an aerobic healing environment and a physical barrier.

Mechanical Mimicry

Electrospun wound dressings exhibit significant tensile strength and flexibility. 

Electrospun nanofibers form a biodegradable mesh that can promote hemostasis.  Additionally, research has shown a wide variety of polymers can allow for the incorporation of a wide range of active pharmaceutical ingredients (APIs).  

1.  Cell Integration with Electrospun PMMA Nanofibers, Microfibers, Ribbons, and Films: A Microscopy Study

2.  Zahedi et.al, “A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages.” Wiley Interscience, December 2009.